IP Library › Granted Patent US 12,246,114
Granted Patent B2
US 12,246,114 · App. 16/872,926 · Granted Mar 11, 2025

Biomedical patches with spatially arranged fibers

Inventor: Matthew R. MacEwan (St. Louis, MO)
Assignee: Washington University
A61L31/04A61L15/26A61L15/44A61L15/64A61L27/18A61L27/54A61L27/58A61L27/60B29C48/18B32B5/022B32B5/26B32B7/02B32B7/12D01D5/0007D01D5/0038D01D5/0061D01D5/0076D04H1/728D04H3/16A61F13/02A61L2300/414A61L2400/12A61L2400/18A61L2430/20A61L2430/32B32B2250/20B32B2262/0276B32B2307/518B32B2307/54B32B2307/726B32B2307/7265B32B2556/00D10B2509/00
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Quick Facts
Patent No.
US 12,246,114
App. No.
16/872,926
Granted
Mar 11, 2025
Kind
B2
Abstract

A three-dimensional electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The three-dimensional electrospun nanofiber scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is coupled to the first layer using a coupling process and includes a plurality of varying densities formed by the second plurality of electrospun polymeric fibers. The first and second layers are configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The three-dimensional electrospun nanofiber scaffold is configured to be applied to the tissue substrate containing the defect.

Claims (37)

1. A three-dimensional electrospun nanofiber scaffold for facilitating tissue repair, the three-dimensional electrospun nanofiber scaffold comprising:

a first plurality of deposited electrospun polymeric nanofibers; and

a second plurality of deposited electrospun polymeric nanofibers,

the second plurality of deposited electrospun polymeric nanofibers being coupled to the first plurality of electrospun polymeric nanofibers,

wherein at least some of the second plurality of deposited electrospun polymeric nanofibers are deposited over a portion of the first plurality of electrospun polymeric nanofibers to form one or more regions comprising a spatial variation between fibers on an outer surface of the three-dimensional electrospun nanofiber scaffold that is different from one or more other regions not on the outer surface of the three-dimensional electrospun nanofiber scaffold,

wherein at least some of the second plurality of deposited electrospun polymeric nanofibers are commingled with the first plurality of electrospun polymeric nanofibers within the first portion,

the three-dimensional electrospun nanofiber scaffold further comprising a surface, the surface comprising a surface pattern formed by one or more of the first plurality of deposited electrospun polymeric nanofibers or the second plurality of deposited electrospun polymeric nanofibers, and

the three-dimensional electrospun nanofiber scaffold further comprising a void.

2. The three-dimensional electrospun nanofiber scaffold of claim 1 , wherein the surface pattern is formed by depositing one or more of the first plurality of deposited electrospun polymeric nanofibers or the second plurality of deposited electrospun polymeric nanofibers on a mask positioned between a conductive collector and a spinneret.

3. The three-dimensional electrospun nanofiber scaffold of claim 1 , wherein the surface pattern is formed by depositing one or more of the first plurality of deposited electrospun polymeric fibers or the second plurality of deposited electrospun polymeric nanofibers directly without a mask on a conductive collector, wherein the conductive collector comprises a pattern.

4. The three-dimensional electrospun nanofiber scaffold of claim 3 , wherein the void is adapted to receive a suture for attaching the three-dimensional electrospun nanofiber scaffold to the tissue to facilitate tissue repair.

5. The three-dimensional electrospun nanofiber scaffold of claim 3 , wherein the tissue comprises one or more of skin, dura mater, heart valve leaflets, cardiac tissue, trachea, gastrointestinal tract, or pericardium.

6. The three-dimensional electrospun nanofiber scaffold of claim 3 , further comprising one or more anisotropic properties.

7. The three-dimensional electrospun nanofiber scaffold of claim 6 , wherein the three-dimensional electrospun nanofiber scaffold comprises a stronger tensile strength in one axis relative to another.

8. The three-dimensional electrospun nanofiber scaffold of claim 3 , wherein the first plurality of electrospun polymeric nanofibers comprises a first polymer comprising glycolic acid, and wherein the second plurality of electrospun polymeric nanofibers comprises a second polymer comprising caprolactone.

9. The three-dimensional electrospun nanofiber scaffold of claim 3 , wherein the first plurality of deposited electrospun polymeric nanofibers and the second plurality of deposited electrospun polymeric nanofibers comprise different polymers.

10. The three-dimensional electrospun nanofiber scaffold of claim 3 , wherein the first plurality of deposited electrospun polymeric nanofibers and the second plurality of deposited electrospun polymeric nanofibers comprise the same polymer.

11. The three-dimensional electrospun nanofiber scaffold of claim 3 , wherein the first plurality of deposited electrospun polymeric nanofibers and the second plurality of deposited electrospun polymeric nanofibers are randomly oriented.

12. A three-dimensional electrospun nanofiber scaffold for facilitating tissue repair, the three-dimensional electrospun nanofiber scaffold comprising:

a first plurality of electrospun polymeric nanofibers;

a second plurality of deposited electrospun polymeric nanofibers; and

a third plurality of deposited electrospun polymeric nanofibers,

wherein the first plurality of electrospun polymeric nanofibers and the third plurality of deposited electrospun polymeric nanofibers form outer surfaces of the three-dimensional electrospun nanofiber scaffold, and wherein the second plurality of deposited electrospun polymeric nanofibers are located between the first plurality of electrospun polymeric nanofibers and the third plurality of deposited electrospun polymeric nanofibers,

wherein one or more of the second plurality of deposited electrospun polymeric nanofibers are deposited over a portion of the first plurality of electrospun polymeric nanofibers, wherein the third plurality of deposited electrospun polymeric nanofibers are deposited over the second plurality of deposited electrospun polymeric nanofibers,

wherein the second plurality of deposited electrospun polymeric nanofibers comprises a spatial variation between fibers that is different from the first plurality of deposited electrospun polymeric nanofibers and the third plurality of deposited electrospun polymeric nanofibers,

wherein the outer surfaces of the three-dimensional electrospun nanofiber scaffold comprises a surface pattern formed by one or more of the first plurality of deposited electrospun polymeric nanofibers or the third plurality of deposited electrospun polymeric nanofibers,

the three-dimensional electrospun nanofiber scaffold further comprising a void.

13. The three-dimensional electrospun nanofiber scaffold of claim 12 , wherein the surface pattern is formed by depositing one or more of the first plurality of deposited electrospun polymeric nanofibers or the third plurality of deposited electrospun polymeric nanofibers on a mask positioned between a conductive collector and a spinneret.

14. The three-dimensional electrospun nanofiber scaffold of claim 12 , wherein the surface pattern is formed by depositing one or more of the first plurality of deposited electrospun polymeric fibers or the third plurality of deposited electrospun polymeric nanofibers directly without a mask on a conductive collector, wherein the conductive collector comprises a pattern.

15. The three-dimensional electrospun nanofiber scaffold of claim 14 , wherein the void is configured to receive a suture for attaching the three-dimensional electrospun nanofiber scaffold to the tissue to facilitate tissue repair.

16. The three-dimensional electrospun nanofiber scaffold of claim 14 , wherein the tissue comprises one or more of skin, tissue, dura mater, heart valve leaflets, cardiac tissue, trachea, gastrointestinal tract, or pericardium.

17. The three-dimensional electrospun nanofiber scaffold of claim 14 , further comprising one or more anisotropic properties.

18. The three-dimensional electrospun nanofiber scaffold of claim 17 , wherein the three-dimensional electrospun nanofiber scaffold comprises a stronger tensile strength in one axis relative to another.

19. The three-dimensional electrospun nanofiber scaffold of claim 14 , wherein the first plurality of electrospun polymeric nanofibers comprises a first polymer comprising glycolic acid, and wherein the second plurality of electrospun polymeric nanofibers comprises a second polymer comprising caprolactone.

20. The three-dimensional electrospun nanofiber scaffold of claim 14 , wherein the first plurality of deposited electrospun polymeric nanofibers and the second plurality of deposited electrospun polymeric nanofibers comprise different polymers.

21. The three-dimensional electrospun nanofiber scaffold of claim 14 , wherein the first plurality of deposited electrospun polymeric nanofibers and the second plurality of deposited electrospun polymeric nanofibers comprise the same polymer.

22. The three-dimensional electrospun nanofiber scaffold of claim 14 , wherein the first plurality of deposited electrospun polymeric nanofibers and the second plurality of deposited electrospun polymeric nanofibers are randomly oriented.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 14, 2020
From: MACEWAN, MATTHEW R.
To: WASHINGTON UNIVERSITY
Reel/Frame 052662/0653 →
Continuity (4)
Continuation 16540779 · Aug 14, 2019
Continuation 16131887 · Sep 14, 2018
Division 14429976
Related Publication 20210001014A1 · Jan 7, 2021
References Cited (400)
US 2068703A · Powdermaker · 1937 [cited by applicant]
US 2241394A · Duffy · 1941 [cited by applicant]
US 3280229A · Simons · 1966 [cited by applicant]
US 3338992A · Kinney · 1967 [cited by applicant]
US 3341394A · Kinney · 1967 [cited by applicant]
US 3502763A · Hartmann · 1970 [cited by applicant]
US 3542615A · Dobo et al. · 1970 [cited by applicant]
US 3692618A · Dorschner et al. · 1972 [cited by applicant]
US 3740302A · Soehngen · 1973 [cited by applicant]
US 3802817A · Matsuki et al. · 1974 [cited by applicant]
US 3849241A · Butin et al. · 1974 [cited by applicant]
US 3909009A · Cvetko et al. · 1975 [cited by applicant]
US 4044404A · Martin et al. · 1977 [cited by applicant]
US 4340563A · Appel et al. · 1982 [cited by applicant]
US 4468428A · Early et al. · 1984 [cited by applicant]
US 4738740A · Pinchuk et al. · 1988 [cited by applicant]
US 4965110A · Berry · 1990 [cited by applicant]
US 5024789A · Berry · 1991 [cited by applicant]
US 5079080A · Schwarz · 1992 [cited by applicant]
US 5306550A · Nishiyama et al. · 1994 [cited by applicant]
US 5464450A · Buscemi et al. · 1995 [cited by applicant]
US 5591335A · Barboza et al. · 1997 [cited by applicant]
US 5626611A · Liu et al. · 1997 [cited by applicant]
US 5634944A · Magram · 1997 [cited by applicant]
US 5795584A · Totakura et al. · 1998 [cited by applicant]
US 5851937A · Wu et al. · 1998 [cited by applicant]
US 5997568A · Liu · 1999 [cited by applicant]
US 6147135A · Yuan et al. · 2000 [cited by applicant]
US 6162535A · Turkevich et al. · 2000 [cited by applicant]
US 6171338B1 · Talja et al. · 2001 [cited by applicant]
US 6180848B1 · Flament et al. · 2001 [cited by applicant]
US 6183670B1 · Torobin et al. · 2001 [cited by applicant]
US 6265333B1 · Dzenis et al. · 2001 [cited by applicant]
US 6306424B1 · Vyakamam et al. · 2001 [cited by applicant]
US 6391060B1 · Ory et al. · 2002 [cited by applicant]
US 6596296B1 · Nelson et al. · 2003 [cited by applicant]
US 6630231B2 · Perez et al. · 2003 [cited by applicant]
US 6649807B2 · Mizutani · 2003 [cited by applicant]
US 6685956B2 · Chu et al. · 2004 [cited by applicant]
US 6689374B2 · Chu et al. · 2004 [cited by applicant]
US 6713011B2 · Chu et al. · 2004 [cited by applicant]
US 6753454B1 · Smith et al. · 2004 [cited by applicant]
US 6790455B2 · Chu et al. · 2004 [cited by applicant]
US 6797655B2 · Rudisill · 2004 [cited by applicant]
US 6946506B2 · Bond et al. · 2005 [cited by applicant]
US 7134857B2 · Andrady et al. · 2006 [cited by applicant]
US 7172765B2 · Chu et al. · 2007 [cited by applicant]
US 7192604B2 · Brown et al. · 2007 [cited by applicant]
US 7655070B1 · Dallas et al. · 2010 [cited by applicant]
US 7759082B2 · Bowlin et al. · 2010 [cited by applicant]
US 7799262B1 · Kim · 2010 [cited by applicant]
US 7846466B2 · Shea et al. · 2010 [cited by applicant]
US 7879093B2 · Wei et al. · 2011 [cited by applicant]
US 7981353B2 · Mitchell et al. · 2011 [cited by applicant]
US 8066932B2 · Xu · 2011 [cited by applicant]
US 8222166B2 · Chu et al. · 2012 [cited by applicant]
US 8273369B2 · Shetty et al. · 2012 [cited by applicant]
US 8652215B2 · Bellamkonda et al. · 2014 [cited by applicant]
US 8728463B2 · Atala et al. · 2014 [cited by applicant]
US 8728817B2 · Ogle et al. · 2014 [cited by applicant]
US 8809212B1 · Dirk et al. · 2014 [cited by applicant]
US 8852621B2 · Patel et al. · 2014 [cited by applicant]
US 9074172B2 · Johnson · 2015 [cited by applicant]
US 9085830B2 · Mitchell et al. · 2015 [cited by applicant]
US 9163331B2 · Atala et al. · 2015 [cited by applicant]
US 9168231B2 · Patel et al. · 2015 [cited by applicant]
US 9345486B2 · Zhang et al. · 2016 [cited by applicant]
US 9393097B2 · McCullen et al. · 2016 [cited by applicant]
US 9476026B2 · Arinzeh et al. · 2016 [cited by applicant]
US 9487893B2 · Moore et al. · 2016 [cited by applicant]
US 9539365B2 · Kasuga et al. · 2017 [cited by applicant]
US 9572909B2 · Simpson et al. · 2017 [cited by applicant]
US 9585666B2 · Yu et al. · 2017 [cited by applicant]
US 9737632B2 · Johnson et al. · 2017 [cited by applicant]
US 9884027B2 · Johnson · 2018 [cited by applicant]
US 9938373B2 · Wang et al. · 2018 [cited by applicant]
US 10016464B2 · Murphy et al. · 2018 [cited by applicant]
US 10080687B2 · MacEwan · 2018 [cited by applicant]
US 10124089B2 · MacEwan · 2018 [cited by examiner]
US 10149749B2 · MacEwan et al. · 2018 [cited by applicant]
US 10166315B2 · Johnson et al. · 2019 [cited by applicant]
US 10227568B2 · Johnson · 2019 [cited by applicant]
US 10231821B2 · Gabriele et al. · 2019 [cited by applicant]
US 10233427B2 · Johnson · 2019 [cited by applicant]
US 10239262B2 · Johnson · 2019 [cited by applicant]
US 10294449B2 · Johnson · 2019 [cited by applicant]
US 10335154B2 · Johnson et al. · 2019 [cited by applicant]
US 10363041B2 · Yu et al. · 2019 [cited by applicant]
US 10381672B2 · Lee et al. · 2019 [cited by applicant]
US 10405963B2 · McAlpine et al. · 2019 [cited by applicant]
US 10406346B2 · Scott-Carnell et al. · 2019 [cited by applicant]
US 10413574B2 · Fong et al. · 2019 [cited by applicant]
US 10420856B2 · Arinzeh et al. · 2019 [cited by applicant]
US 10441403B1 · MacEwan et al. · 2019 [cited by applicant]
US 10441685B2 · MacEwan · 2019 [cited by examiner]
US 10588734B2 · MacEwan et al. · 2020 [cited by applicant]
US 10617512B2 · MacEwan · 2020 [cited by applicant]
US 10632228B2 · MacEwan · 2020 [cited by applicant]
US 10682444B2 · MacEwan · 2020 [cited by examiner]
US 10738152B2 · Wang et al. · 2020 [cited by applicant]
US 10888409B2 · MacEwan et al. · 2021 [cited by applicant]
US 11000358B2 · MacEwan et al. · 2021 [cited by applicant]
US 11071617B2 · MacEwan et al. · 2021 [cited by applicant]
US 11096772B1 · MacEwan et al. · 2021 [cited by applicant]
US 11173234B2 · MacEwan · 2021 [cited by examiner]
US 11176234B2 · Andersson et al. · 2021 [cited by applicant]
US 11224677B2 · MacEwan · 2022 [cited by applicant]
US 11253635B2 · MacEwan · 2022 [cited by applicant]
US 11311366B2 · MacEwan et al. · 2022 [cited by applicant]
US 11471260B2 · MacEwan et al. · 2022 [cited by applicant]
US 11596717B2 · MacEwan · 2023 [cited by applicant]
US 11826487B2 · MacEwan · 2023 [cited by applicant]
US 20020081732A1 · Bowlin et al. · 2002 [cited by applicant]
US 20020090725A1 · Simpson et al. · 2002 [cited by applicant]
US 20020173213A1 · Chu et al. · 2002 [cited by applicant]
US 20020192251A1 · Collin · 2002 [cited by applicant]
US 20030004579A1 · Rousseau et al. · 2003 [cited by applicant]
US 20030054035A1 · Chu et al. · 2003 [cited by applicant]
US 20040013819A1 · Hou et al. · 2004 [cited by applicant]
US 20040018226A1 · Wnek et al. · 2004 [cited by applicant]
US 20040037813A1 · Simpson et al. · 2004 [cited by applicant]
US 20040096532A1 · Dubson et al. · 2004 [cited by applicant]
US 20040102614A1 · Islam et al. · 2004 [cited by applicant]
US 20050104258A1 · Lennhoff · 2005 [cited by applicant]
US 20050167311A1 · Tonsfeldt et al. · 2005 [cited by applicant]
US 20050222591A1 · Gingras et al. · 2005 [cited by applicant]
US 20060014460A1 · Sele et al. · 2006 [cited by applicant]
US 20060085063A1 · Shastri et al. · 2006 [cited by applicant]
US 20060094320A1 · Chen et al. · 2006 [cited by applicant]
US 20060153904A1 · Smith et al. · 2006 [cited by applicant]
US 20060193578A1 · Ouderkirk et al. · 2006 [cited by applicant]
US 20060204539A1 · Atala et al. · 2006 [cited by applicant]
US 20060240110A1 · Kiick et al. · 2006 [cited by applicant]
US 20060246798A1 · Reneker et al. · 2006 [cited by applicant]
US 20060263417A1 · Lelkes et al. · 2006 [cited by applicant]
US 20060264140A1 · Andrady et al. · 2006 [cited by applicant]
US 20070073344A1 · Jahns et al. · 2007 [cited by applicant]
US 20070152378A1 · Kim et al. · 2007 [cited by applicant]
US 20070155273A1 · Chu et al. · 2007 [cited by applicant]
US 20070225631A1 · Bowlin et al. · 2007 [cited by applicant]
US 20070269481A1 · Li et al. · 2007 [cited by applicant]
US 20080065123A1 · Yli-Urpo et al. · 2008 [cited by applicant]
US 20080112998A1 · Wang et al. · 2008 [cited by applicant]
US 20080207798A1 · Hellring et al. · 2008 [cited by applicant]
US 20080208358A1 · Bellamkonda et al. · 2008 [cited by applicant]
US 20080220042A1 · Hashi et al. · 2008 [cited by applicant]
US 20080237934A1 · Reneker et al. · 2008 [cited by applicant]
US 20090028921A1 · Arinzeh · 2009 [cited by applicant]
US 20090074832A1 · Zussman et al. · 2009 [cited by applicant]
US 20090075354A1 · Reneker et al. · 2009 [cited by applicant]
US 20090155326A1 · Mack et al. · 2009 [cited by applicant]
US 20090162468A1 · Barinov et al. · 2009 [cited by applicant]
US 20090171467A1 · Mann et al. · 2009 [cited by applicant]
US 20090202616A1 · Chong et al. · 2009 [cited by applicant]
US 20090214614A1 · Everland et al. · 2009 [cited by applicant]
US 20090228021A1 · Leung · 2009 [cited by applicant]
US 20090317446A1 · Tan et al. · 2009 [cited by applicant]
US 20100003305A1 · Pattanaik · 2010 [cited by applicant]
US 20100047309A1 · Lu et al. · 2010 [cited by applicant]
US 20100061962A1 · Li · 2010 [cited by applicant]
US 20100076377A1 · Ehrenreich et al. · 2010 [cited by applicant]
US 20100092687A1 · Sumida et al. · 2010 [cited by applicant]
US 20100093093A1 · Leong et al. · 2010 [cited by applicant]
US 20100119564A1 · Kasuga et al. · 2010 [cited by applicant]
US 20100120115A1 · Ogle et al. · 2010 [cited by applicant]
US 20100137902A1 · Lee et al. · 2010 [cited by applicant]
US 20100166854A1 · Kohn et al. · 2010 [cited by applicant]
US 20100174368A1 · Lynch et al. · 2010 [cited by applicant]
US 20100179659A1 · Li et al. · 2010 [cited by applicant]
US 20100185219A1 · Gertzman et al. · 2010 [cited by applicant]
US 20100190254A1 · Chian et al. · 2010 [cited by applicant]
US 20100233115A1 · Patel et al. · 2010 [cited by applicant]
US 20100273258A1 · Lannutti et al. · 2010 [cited by applicant]
US 20100291182A1 · Palasis et al. · 2010 [cited by applicant]
US 20100292791A1 · Lu et al. · 2010 [cited by applicant]
US 20100297208A1 · Fry et al. · 2010 [cited by applicant]
US 20100330419A1 · Cui et al. · 2010 [cited by applicant]
US 20100331980A1 · Lee et al. · 2010 [cited by applicant]
US 20110014289A1 · Datta et al. · 2011 [cited by applicant]
US 20110087277A1 · Vola et al. · 2011 [cited by applicant]
US 20110098826A1 · Mauck et al. · 2011 [cited by applicant]
US 20110101571A1 · Reneker · 2011 [cited by applicant]
US 20110111012A1 · Pepper et al. · 2011 [cited by applicant]
US 20110150973A1 · Bowlin et al. · 2011 [cited by applicant]
US 20110152897A1 · Bates · 2011 [cited by applicant]
US 20110174158A1 · Walls et al. · 2011 [cited by applicant]
US 20110180951A1 · Teo et al. · 2011 [cited by applicant]
US 20110242310A1 · Beebe, Jr. et al. · 2011 [cited by applicant]
US 20110280919A1 · Moloye-Olabisi et al. · 2011 [cited by applicant]
US 20110287082A1 · Smith et al. · 2011 [cited by applicant]
US 20120015331A1 · Wood et al. · 2012 [cited by applicant]
US 20120029654A1 · Xu et al. · 2012 [cited by applicant]
US 20120040581A1 · Kim · 2012 [cited by applicant]
US 20120123342A1 · Andrews et al. · 2012 [cited by applicant]
US 20120165957A1 · Everland et al. · 2012 [cited by applicant]
US 20120221025A1 · Simpson et al. · 2012 [cited by applicant]
US 20120225039A1 · Li et al. · 2012 [cited by applicant]
US 20120265300A1 · Mauck et al. · 2012 [cited by applicant]
US 20120310260A1 · Hamlin et al. · 2012 [cited by applicant]
US 20120330437A1 · El-Kurdi et al. · 2012 [cited by applicant]
US 20130030548A1 · Ling · 2013 [cited by applicant]
US 20130035704A1 · Dudai · 2013 [cited by applicant]
US 20130110138A1 · Hurtado · 2013 [cited by applicant]
US 20130115457A1 · Haynie et al. · 2013 [cited by applicant]
US 20130144249A1 · Fenton et al. · 2013 [cited by applicant]
US 20130197663A1 · MacEwan et al. · 2013 [cited by applicant]
US 20130251762A1 · Wei et al. · 2013 [cited by applicant]
US 20130338791A1 · McCullen et al. · 2013 [cited by applicant]
US 20140004159A1 · Xie et al. · 2014 [cited by applicant]
US 20140030315A1 · Johnson · 2014 [cited by applicant]
US 20140081297A1 · Hoke et al. · 2014 [cited by applicant]
US 20140128345A1 · Woodrow et al. · 2014 [cited by applicant]
US 20140272225A1 · Johnson · 2014 [cited by applicant]
US 20140288663A1 · Borden et al. · 2014 [cited by applicant]
US 20140303727A1 · Atlas et al. · 2014 [cited by applicant]
US 20140322512A1 · Pham et al. · 2014 [cited by applicant]
US 20150030659A1 · Langer et al. · 2015 [cited by applicant]
US 20150045818A1 · Kim et al. · 2015 [cited by applicant]
US 20150132423A1 · Johnson · 2015 [cited by applicant]
US 20150133454A1 · Choy et al. · 2015 [cited by applicant]
US 20150190285A1 · MacEwan · 2015 [cited by applicant]
US 20150250927A1 · MacEwan · 2015 [cited by applicant]
US 20150297791A1 · Patel et al. · 2015 [cited by applicant]
US 20150342719A1 · Chen et al. · 2015 [cited by applicant]
US 20160022873A1 · Besner et al. · 2016 [cited by applicant]
US 20160083692A1 · Hardy et al. · 2016 [cited by applicant]
US 20160083868A1 · Park · 2016 [cited by applicant]
US 20160136330A1 · Benkirane-Jessel et al. · 2016 [cited by applicant]
US 20160302869A1 · Chopra · 2016 [cited by applicant]
US 20160317706A1 · Johnson · 2016 [cited by applicant]
US 20170095591A1 · Zuhaib et al. · 2017 [cited by applicant]
US 20170119886A1 · Johnson et al. · 2017 [cited by applicant]
US 20170182206A1 · Johnson et al. · 2017 [cited by applicant]
US 20170182211A1 · Raxworthy et al. · 2017 [cited by applicant]
US 20170203004A1 · Murphy et al. · 2017 [cited by applicant]
US 20170319323A1 · MacEwan et al. · 2017 [cited by applicant]
US 20170319742A1 · Johnson et al. · 2017 [cited by applicant]
US 20170326270A1 · MacEwan · 2017 [cited by applicant]
US 20180116973A1 · Johnson · 2018 [cited by applicant]
US 20180161185A1 · Kresslein et al. · 2018 [cited by applicant]
US 20180174367A1 · Marom et al. · 2018 [cited by applicant]
US 20180221537A1 · Johnson et al. · 2018 [cited by applicant]
US 20180237952A1 · Johnson et al. · 2018 [cited by applicant]
US 20180245243A1 · Krieger et al. · 2018 [cited by applicant]
US 20180263919A1 · Hoke et al. · 2018 [cited by applicant]
US 20180368917A1 · Dekel et al. · 2018 [cited by applicant]
US 20190015563A1 · MacEwan · 2019 [cited by applicant]
US 20190021837A1 · MacEwan et al. · 2019 [cited by applicant]
US 20190046692A1 · Shefi et al. · 2019 [cited by applicant]
US 20190054036A1 · Johnson et al. · 2019 [cited by applicant]
US 20190102880A1 · Parpara et al. · 2019 [cited by applicant]
US 20190105128A1 · Velazquez et al. · 2019 [cited by applicant]
US 20190134267A1 · Francis et al. · 2019 [cited by applicant]
US 20190134570A1 · Pintauro et al. · 2019 [cited by applicant]
US 20190153398A1 · Johnson · 2019 [cited by applicant]
US 20190175786A1 · Cohen et al. · 2019 [cited by applicant]
US 20190249127A1 · Johnson · 2019 [cited by applicant]
US 20190269829A1 · Johnson et al. · 2019 [cited by applicant]
US 20190271098A1 · Johnson et al. · 2019 [cited by applicant]
US 20190282351A1 · Mathisen et al. · 2019 [cited by applicant]
US 20190328393A1 · Yu et al. · 2019 [cited by applicant]
US 20190330419A1 · Song et al. · 2019 [cited by applicant]
US 20190350688A1 · Hurtado et al. · 2019 [cited by applicant]
US 20190365520A1 · MacEwan et al. · 2019 [cited by applicant]
US 20190365958A1 · MacEwan · 2019 [cited by applicant]
US 20190374227A1 · Johnson et al. · 2019 [cited by applicant]
US 20200000570A1 · MacEwan et al. · 2020 [cited by applicant]
US 20200046883A1 · Martin et al. · 2020 [cited by applicant]
US 20200060800A1 · MacEwan et al. · 2020 [cited by applicant]
US 20200197153A1 · MacEwan et al. · 2020 [cited by applicant]
US 20200229679A1 · Zhao et al. · 2020 [cited by applicant]
US 20200242767A1 · Zhao et al. · 2020 [cited by applicant]
US 20200277711A1 · Xie · 2020 [cited by applicant]
US 20200324021A1 · Van Belleghem et al. · 2020 [cited by applicant]
US 20200376170A1 · Ahn et al. · 2020 [cited by applicant]
US 20200390932A1 · MacEwan · 2020 [cited by applicant]
US 20210001014A1 · Macewan · 2021 [cited by applicant]
US 20210030525A1 · MacEwan et al. · 2021 [cited by applicant]
US 20210052362A1 · MacEwan et al. · 2021 [cited by applicant]
US 20210128792A1 · Dunbar et al. · 2021 [cited by applicant]
US 20210228782A1 · MacEwan · 2021 [cited by applicant]
US 20210236691A1 · MacEwan · 2021 [cited by applicant]
US 20210267746A1 · MacEwan et al. · 2021 [cited by applicant]
US 20210338408A1 · MacEwan et al. · 2021 [cited by applicant]
US 20210353834A1 · MacEwan · 2021 [cited by applicant]
US 20220175510A1 · MacEwan et al. · 2022 [cited by applicant]
US 20220249743A1 · MacEwan · 2022 [cited by applicant]
US 20230030107A1 · MacEwan et al. · 2023 [cited by applicant]
US 20230074964A1 · MacEwan et al. · 2023 [cited by applicant]
AU 2011268321B2 · 2015 [cited by applicant]
AU 2012390291B2 · 2017 [cited by applicant]
AU 2017232208A1 · 2017 [cited by applicant]
CA 2094908C · 2000 [cited by applicant]
CA 2802482A1 · 2011 [cited by applicant]
CA 2386810C · 2013 [cited by applicant]
CN 1994476A · 2007 [cited by applicant]
CN 102260963A · 2011 [cited by applicant]
CN 102691176A · 2012 [cited by applicant]
CN 103599562A · 2014 [cited by applicant]
CN 104894750A · 2015 [cited by applicant]
DE 102014107826A1 · 2014 [cited by applicant]
EP 0314109A2 · 1989 [cited by applicant]
EP 0515522B1 · 1993 [cited by applicant]
EP 0571415B1 · 1995 [cited by applicant]
EP 0757127A1 · 1997 [cited by applicant]
EP 2045375B1 · 2011 [cited by applicant]
EP 2358301B1 · 2011 [cited by applicant]
EP 2599858A2 · 2013 [cited by applicant]
EP 2582868B1 · 2018 [cited by applicant]
EP 3508641B1 · 2020 [cited by applicant]
EP 2897561B1 · 2020 [cited by applicant]
EP 3741896A1 · 2020 [cited by applicant]
EP 3824853B1 · 2023 [cited by applicant]
GB 1286858A · 1972 [cited by applicant]
GB 2181207A · 1987 [cited by applicant]
GB 2195251A · 1988 [cited by applicant]
JP H03161563A · 1991 [cited by applicant]
JP 3487722B2 · 2004 [cited by applicant]
JP 2005534828A · 2005 [cited by applicant]
JP 2006283241A · 2006 [cited by applicant]
JP 2006328562A · 2006 [cited by applicant]
JP 2007303031A · 2007 [cited by applicant]
JP 2007303021A · 2007 [cited by applicant]
JP 2008223186A · 2008 [cited by applicant]
JP 2009061109A · 2009 [cited by applicant]
JP 2011059786A · 2011 [cited by applicant]
JP 2011509786A · 2011 [cited by applicant]
JP 4769871B2 · 2011 [cited by applicant]
JP 4979264B2 · 2012 [cited by applicant]
JP 2012528464A · 2012 [cited by applicant]
JP 2013518996A · 2013 [cited by applicant]
JP 2013534979A · 2013 [cited by applicant]
JP 6295258A · 2018 [cited by applicant]
JP 6328672B2 · 2018 [cited by applicant]
KR 100439871B1 · 2004 [cited by applicant]
KR 20060118937A · 2006 [cited by applicant]
KR 20070047873A · 2007 [cited by applicant]
KR 1020070047873A · 2007 [cited by applicant]
KR 101703095A · 2013 [cited by applicant]
SG 186379A1 · 2013 [cited by applicant]
SG 11201502207W · 2015 [cited by applicant]
WO 1991001695A1 · 1991 [cited by applicant]
WO 2001027365A1 · 2001 [cited by applicant]
WO 200200149A1 · 2002 [cited by applicant]
WO 2004016839A1 · 2004 [cited by applicant]
WO 2006096791A2 · 2006 [cited by applicant]
WO 2006123858A1 · 2006 [cited by applicant]
WO 2007086910A2 · 2007 [cited by applicant]
WO 2008069760A1 · 2008 [cited by applicant]
WO 2009093023A2 · 2009 [cited by applicant]
WO 2010041944A1 · 2010 [cited by applicant]
WO 2010042651A1 · 2010 [cited by applicant]
WO 2010112564A1 · 2010 [cited by applicant]
WO 2010138619A2 · 2010 [cited by applicant]
WO 2011095141A1 · 2011 [cited by applicant]
WO 2011106822A1 · 2011 [cited by applicant]
WO 2011159889A2 · 2011 [cited by applicant]
WO 2012080706A2 · 2012 [cited by applicant]
WO 2013025819A2 · 2013 [cited by applicant]
WO 2013050428A1 · 2013 [cited by applicant]
WO 2013078051A1 · 2013 [cited by applicant]
WO 2013106822A1 · 2013 [cited by applicant]
WO 2014031721A1 · 2014 [cited by applicant]
WO 2014046669A1 · 2014 [cited by applicant]
WO 2014145864A1 · 2014 [cited by applicant]
WO 2014152906A2 · 2014 [cited by applicant]
WO 2015048224A1 · 2015 [cited by applicant]
WO 2015116917A1 · 2015 [cited by applicant]
WO 2015157485A1 · 2015 [cited by applicant]
WO 2015153011A1 · 2015 [cited by applicant]
WO 2016176559A1 · 2016 [cited by applicant]
WO 2017024263A1 · 2017 [cited by applicant]
WO 2017035500A1 · 2017 [cited by applicant]
WO 2017044982A1 · 2017 [cited by applicant]
WO 2017079328A1 · 2017 [cited by applicant]
WO 2017196325A1 · 2017 [cited by applicant]
WO 2018112203A1 · 2018 [cited by applicant]
WO 2018144858A1 · 2018 [cited by applicant]
WO 2023007443A2 · 2023 [cited by applicant]
WO 2023007444A1 · 2023 [cited by applicant]
Chinese Second Office Action Issued for Application No. 201680087078.9, dated Jul. 14, 2021 with translation (23 pages). [cited by applicant]
Gnavi et al., “The Influence of Electrospun Fibre Size on Schwann Cell Behaviour and Axonal Outgrowth,” Materials Science and Engineering: C 48: 620-631 (2015). [cited by applicant]
Kim et al., “A Controlled Design of Aligned and Random Nanofibers for 3D Bi-functionalized Nerve Conduits Fabricated via a Novel Electrospinning Set-up,” Scientific Reports, 6: 23761 (2016). https://doi.org/10.1038/srep… [cited by applicant]
MacEwan et al., “What makes the optimal wound healing material? A review of current science and introduction of a synthetic nanofabricated wound care scaffold,” Cureus, 9(10) (2017) 9 pages. [cited by applicant]
Panseri et al., “Electrospun micro-and nanofiber tubes for functional nervous regeneration in sciatic nerve transections,” BMC Biotechnology, 8(39), (2008) 12 pages. https://doi.org/10.1186/1472-6750-8-39. [cited by applicant]
Quan et al., “Aligned fibers enhance nerve guide conduits when bridging peripheral nerve defects focused on early repair stage,” Neural Regeneration Research, 14(5): 903-912 (2019). doi: 10.4103/1673-5374.249239. PMID: … [cited by applicant]
PCT International Search Report and Written Opinion issued for Application No. PCT/IB2022/057029, dated Oct. 18, 2022 (8 pages). [cited by applicant]
PCT International Search Report and Written Opinion issued for Application No. PCT/IB2022/057028, dated Jan. 6, 2023 (9 pages). [cited by applicant]
PCT International Search Report and Written Opinion issued for Application No. PCT/US2022/075995, dated Feb. 3, 2023 (18 pages). [cited by applicant]
Report and Recommendation filed May 25, 2023, in Case No. 1:20-cv-00980-CFC-JLH, Document 201, [cited by applicant]
Joint Appendix to Claim Construction Brief filed Mar. 31, 2023, in Case No. 1:20-cv-00980-CFC-JLH, Document 192, [cited by applicant]
Joint Claim Construction Brief Regarding U.S. Pat. No. 11,224,677, filed Mar. 31, 2023, in Case No. 1:20-CV-00980-FCF-JLH, Document 191, [cited by applicant]
Joint Claim Construction Chart, filed Mar. 30, 2023, in Case No. 1:20-cv-00980-CFC-JLH, Document 188, [cited by applicant]
Report and Recommendation filed Oct. 12, 2022, in Case No. 1:20-cv-00980-CFC-JLH, Document 147, [cited by applicant]
Joint Claim Construction Brief, filed Jul. 29, 2022, in Case No. 1:20-cv-00980-FCF-JLH, Document 120, [cited by applicant]
Joint Appendix to Claim Construction Brief filed Jul. 29, 2022, Document 121, in Case No. 1:20-cv-00980-CFC-JLH, [cited by applicant]
Joint Claim Construction Chart, filed May 10, 2022, Document 99, in Case No. 1:20-cv-00980-CFC-JLH, [cited by applicant]
Joint Claim Construction Chart, filed Feb. 7, 2023, Document 172, in Case No. 1:20-cv-00980-CFC-JLH, [cited by applicant]
Plaintiffs [cited by applicant]
Bognitzki et al., “Preparation of Fibers with Nanoscaled Morphologies: Electrospinning of Polmer Blends,” Polymer Engineering and Science, 41(6): 982-989 (2001). [cited by applicant]
Cited By (1)
US 12,564,658