IP Library › Granted Patent US 12,516,115
Granted Patent B2
US 12,516,115 · App. 18/450,863 · Granted Jan 6, 2026

Composition for prophylaxis or treatment of IL-8 related diseases

Inventors: Ayako Kakiuchi (Kanagawa, JP); Atsuhiko Kato (Shizuoka, JP); Shuji Hayashi (Shizuoka, JP); Izumi Yanagisawa (Kanagawa, JP); Ryo Konno (Saitama, JP); Sachiho Netsu (Saitama, JP); Tadashi Sankai (Ibaraki, JP)
Assignees: CHUGAI SEIYAKU KABUSHIKI KAISHA; JICHI MEDICAL UNIVERSITY; NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION
C07K16/244A61K39/395A61K45/00A61P1/16A61P11/00A61P13/12A61P15/00A61P15/08A61P17/06A61P29/00A61P43/00C07K16/2866A61K2039/505A61K2039/507C07K16/24C07K2317/24C07K2317/31C07K2317/52C07K2317/56C07K2317/565C07K2317/567C07K2317/92C07K2317/94
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Quick Facts
Patent No.
US 12,516,115
App. No.
18/450,863
Granted
Jan 6, 2026
Kind
B2
Abstract

For example, therapeutic methods and the like for novel IL-8-related diseases using an IL-8 signal inhibitor are provided. Alternatively, for example, therapeutic methods and the like for known or novel IL-8-related diseases using a novel anti-IL-8 antibody are provided.

Claims (24)

1 . A method of inhibiting IL-8, which comprises administering an anti-IL-8 antibody that binds to human IL-8 to a subject in need thereof,

wherein the subject suffers from an IL-8-related disease selected from the group consisting of chronic obstructive pulmonary disease (COPD), cystic fibrosis, psoriasis, hepatic fibrosis, renal fibrosis, and pulmonary fibrosis, and

wherein the anti-IL-8 antibody comprises:

(a) the amino acid sequence of SEQ ID NO: 23 as HVR-H1,

(b) the amino acid sequence of SEQ ID NO: 29 as HVR-H2,

(c) the amino acid sequence of SEQ ID NO: 30 as HVR-H3,

(d) the amino acid sequence of SEQ ID NO: 26 as HVR-L1,

(e) the amino acid sequence of SEQ ID NO: 31 as HVR-L2, and

(f) the amino acid sequence of SEQ ID NO: 32 as HVR-L3.

2 . The method of claim 1 , wherein the anti-IL-8 antibody comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 34 and a light chain variable region comprising the amino acid sequence of SEQ ID NO: 35.

3 . The method of claim 2 , wherein the anti-IL-8 antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO: 36 and a light chain comprising the amino acid sequence of SEQ ID NO: 38.

4 . The method of claim 2 , wherein the anti-IL-8 antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO: 37 and a light chain comprising the amino acid sequence of SEQ ID NO: 38.

5 . The method of claim 1 , wherein the disease is COPD.

6 . The method of claim 1 , wherein the disease is cystic fibrosis.

7 . The method of claim 1 , wherein the disease is psoriasis.

8 . The method of claim 1 , wherein the disease is hepatic fibrosis.

9 . The method of claim 1 , wherein the disease is renal fibrosis.

10 . The method of claim 1 , wherein the disease is pulmonary fibrosis.

11 . The method of claim 2 , wherein the disease is COPD.

12 . The method of claim 2 , wherein the disease is cystic fibrosis.

13 . The method of claim 2 , wherein the disease is psoriasis.

14 . The method of claim 2 , wherein the disease is hepatic fibrosis.

15 . The method of claim 2 , wherein the disease is renal fibrosis.

16 . The method of claim 2 , wherein the disease is pulmonary fibrosis.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 18, 2023
From: KAKIUCHI, AYAKO; KATO, ATSUHIKO; HAYASHI, SHUJI; YANAGISAWA, IZUMI
To: CHUGAI SEIYAKU KABUSHIKI KAISHA
Reel/Frame 064631/0955 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 18, 2023
From: SANKAI, TADASHI
To: NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION
Reel/Frame 064631/0980 →
NUNC PRO TUNC ASSIGNMENT Recorded Aug 18, 2023
From: KONNO, RYO
To: JICHI MEDICAL UNIVERSITY
Reel/Frame 064631/0991 →
NUNC PRO TUNC ASSIGNMENT Recorded Aug 18, 2023
From: NETSU, SACHIHO
To: JICHI MEDICAL UNIVERSITY
Reel/Frame 064632/0004 →
Priority Claims (1)
JP 2016-154174 · Aug 5, 2016 · national
Continuity (3)
Division 17333256 · May 28, 2021
Division 16323142
Related Publication 20240083996A1 · Mar 14, 2024
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