IP Library › Granted Patent US 12,624,086
Granted Patent B2
US 12,624,086 · App. 17/290,185 · Granted May 12, 2026

Materials and methods for treating cancer

Inventors: Cameron Durrant (Oxford, FL); Dale Chappell (Dolores, CO); Saad J. Kenderian (Rochester, MN); Rosalie M. Sterner (Claremont, MN); Michelle J. Cox (Rochester, MN); Reona Sakemura (Rochester, MN)
Assignee: Mayo Foundation for Medical Education and Research
C07K14/70596A61K31/7105A61K38/1774A61K38/465A61K39/3955A61K40/11A61K40/31A61K40/4211A61P35/00C07K14/70578A61K48/00A61K2239/38A61K2239/48
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Quick Facts
Patent No.
US 12,624,086
App. No.
17/290,185
Granted
May 12, 2026
Kind
B2
Abstract

This document provides methods and materials involved in treating cancer. For example, chimeric antigen receptor T cells having reduced levels of GM-CSF are provided. Also provided as methods for making and using chimeric antigen receptor T cells having reduced levels of GM-CSF.

Claims (11)

1 . A method for enhancing anti-tumor efficacy of chimeric antigen receptor-expressing T19-cell (CAR T19-cell) therapy in a subject having cancer, the method comprising administering to the subject CAR-T19 cells having a granulocyte-macrophage colony-stimulating factor (GM-CSF) gene knockout (GM-CSF k/o CAR-T19 cells), wherein administration of the GM-CSF k/o CAR-T19 cells reduces tumor burden compared to tumor burden reduction by administration of CAR-T19 cells lacking said GM-CSF gene knockout.

2 . The method of claim 1 , further comprising administering to the subject an anti-hGM-CSF antibody, wherein the anti-hGM-CSF antibody is a recombinant anti-hGM-CSF antibody that binds to and neutralizes human GM-CSF.

3 . The method of claim 2 , wherein the administration of (i) the GM-CSF k/o CAR-T19 cells or (ii) the GM-CSF k/o CAR-T19 cells and the anti-hGM-CSF antibody decreases or prevents CD14 + myeloid cell trafficking to a central nervous system (CNS) of the subject, wherein a high level of CD14 + myeloid cells in the CNS of the subject is indicative of neurotoxicity.

4 . The method of claim 2 , wherein an objective response rate of the subject administered the anti-hGM-CSF antibody is improved compared to a subject that is not administered the anti-hGM-CSF antibody.

5 . The method of claim 4 , wherein the objective response rate is a complete response rate or a partial response rate.

6 . The method of claim 2 , wherein a progression free response and/or survival of the subject is improved compared to a subject that is not administered the anti-hGM-CSF antibody.

7 . The method of claim 6 , wherein the survival is overall survival of the subject.

8 . The method of claim 2 , wherein the anti-hGM-CSF antibody is administered to the subject after administration of the GM-CSF k/o CAR-T19 cells.

9 . The method of claim 1 , wherein the cancer is lymphoma or a leukemia.

10 . The method of claim 9 , wherein the lymphoma is a diffuse large B cell lymphoma (DLBCL).

11 . The method of claim 9 , wherein the leukemia is acute lymphoblastic leukemia (ALL).

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 21, 2024
From: TARAN THERAPEUTICS, INC.
To: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Reel/Frame 069658/0968 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 20, 2024
From: HUMANIGEN, INC.
To: TARAN THERAPEUTICS, INC.
Reel/Frame 069348/0868 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 5, 2022
From: KENDERIAN, SAAD J.; STERNER, ROSALIE M.; COX, MICHELLE J.; SAKEMURA, REONA
To: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Reel/Frame 058558/0644 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 21, 2021
From: DURRANT, CAMERON; CHAPPELL, DALE
To: HUMANIGEN, INC.
Reel/Frame 058441/0630 →
Continuity (2)
Provisional Application 62753485 · Oct 31, 2018
Related Publication 20220040229A1 · Feb 10, 2022
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